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Oncotarget|August 27, 2016
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancerJianchang Qian, Yaqing Chen, Tao Meng, et al.Bioorganic & Medicinal Chemistry Letters|November 10, 2009
Incorporation of water-solubilizing groups in pyrazolopyrimidine mTOR inhibitors: discovery of highly potent and selective analogs with improved human microsomal stabilityDavid J Richard, Jeroen C Verheijen, Kevin Curran, et al.Cell Chemical Biology|November 3, 2019
Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting AgentsPieter H Bos, Emily R Lowry, Jonathon Costa, et al.Bioorganic & Medicinal Chemistry Letters|May 26, 2009
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACEChunchun Zhang, Frank Lovering, Mark Behnke, et al.Journal of Medicinal Chemistry|February 14, 2008
Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacyArie Zask, Joshua Kaplan, Lourdes Toral-Barza, et al.Bioorganic & Medicinal Chemistry Letters|March 16, 2010
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitorsArie Zask, Jeroen C Verheijen, David J Richard, et al.Bioorganic & Medicinal Chemistry Letters|January 22, 2010
Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituentKevin J Curran, Jeroen C Verheijen, Joshua Kaplan, et al.Bioorganic & Medicinal Chemistry Letters|July 21, 2004
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitorsArie Zask, Gary Birnberg, Katherine Cheung, et al.Journal of Medicinal Chemistry|November 18, 2009
Morpholine derivatives greatly enhance the selectivity of mammalian target of rapamycin (mTOR) inhibitorsArie Zask, Joshua Kaplan, Jeroen C Verheijen, et al.Bioorganic & Medicinal Chemistry Letters|March 5, 2005
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitorsArie Zask, Joshua Kaplan, XueMei Du, et al.Pageof 6