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Arthur Christopoulos

Showing results (111-120 of 331) with videos related to

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Biochemical Pharmacology|June 12, 2016
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptorGeorgina L Thompson, J Robert Lane, Thomas Coudrat, et al.
The Journal of Biological Chemistry|November 17, 2011
A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulationMeritxell Canals, J Robert Lane, Adriel Wen, et al.
Molecular Endocrinology (Baltimore, Md.)|July 19, 2013
Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryCassandra Koole, Emilia E Savage, Arthur Christopoulos, et al.
Endocrinology|February 2, 2013
Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulatorsKatie Leach, Adriel Wen, Anna E Cook, et al.
Biochemical Pharmacology|May 8, 2020
Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonismKathy Sengmany, Shane D Hellyer, Arthur Christopoulos, et al.
Bioorganic & Medicinal Chemistry Letters|May 27, 2011
The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptorLuigi Aurelio, Arthur Christopoulos, Bernard L Flynn, et al.
Endocrinology|July 17, 2012
Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptorKatie Leach, Adriel Wen, Anna E Davey, et al.
Journal of Medicinal Chemistry|June 12, 2009
Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenesLuigi Aurelio, Celine Valant, Bernard L Flynn, et al.
Molecular Pharmacology|August 17, 2006
A critical role for the short intracellular C terminus in receptor activity-modifying protein functionMadhara Udawela, George Christopoulos, Maria Morfis, et al.
Bioorganic & Medicinal Chemistry Letters|March 3, 2012
Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT₂C agonistsRichard J Conway, Celine Valant, Arthur Christopoulos, et al.
Pageof 34

Showing results (111-120 of 331) with videos related to

Sort By:
Pageof 34
Biochemical Pharmacology|June 12, 2016
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptorGeorgina L Thompson, J Robert Lane, Thomas Coudrat, et al.
The Journal of Biological Chemistry|November 17, 2011
A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulationMeritxell Canals, J Robert Lane, Adriel Wen, et al.
Molecular Endocrinology (Baltimore, Md.)|July 19, 2013
Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryCassandra Koole, Emilia E Savage, Arthur Christopoulos, et al.
Endocrinology|February 2, 2013
Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulatorsKatie Leach, Adriel Wen, Anna E Cook, et al.
Biochemical Pharmacology|May 8, 2020
Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonismKathy Sengmany, Shane D Hellyer, Arthur Christopoulos, et al.
Bioorganic & Medicinal Chemistry Letters|May 27, 2011
The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptorLuigi Aurelio, Arthur Christopoulos, Bernard L Flynn, et al.
Endocrinology|July 17, 2012
Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptorKatie Leach, Adriel Wen, Anna E Davey, et al.
Journal of Medicinal Chemistry|June 12, 2009
Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenesLuigi Aurelio, Celine Valant, Bernard L Flynn, et al.
Molecular Pharmacology|August 17, 2006
A critical role for the short intracellular C terminus in receptor activity-modifying protein functionMadhara Udawela, George Christopoulos, Maria Morfis, et al.
Bioorganic & Medicinal Chemistry Letters|March 3, 2012
Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT₂C agonistsRichard J Conway, Celine Valant, Arthur Christopoulos, et al.
Pageof 34