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Journal of Medicinal Chemistry|October 3, 2015
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)Snahel Patel, Seth F Harris, Paul Gibbons, et al.The Journal of Experimental Medicine|October 30, 2013
Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degenerationChristine D Pozniak, Arundhati Sengupta Ghosh, Alvin Gogineni, et al.Neurobiology of Disease|December 12, 2018
Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALSArundhati Sengupta-Ghosh, Sara L Dominguez, Luke Xie, et al.Proceedings of the National Academy of Sciences of the United States of America|October 17, 2018
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brainKim Newton, Debra L Dugger, Arundhati Sengupta-Ghosh, et al.Iscience|November 15, 2023
TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse modelsSara L Dominguez, Benjamin I Laufer, Arundhati Sengupta Ghosh, et al.Annals of Clinical and Translational Neurology|January 11, 2022
A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALSJonathan S Katz, Jeffrey D Rothstein, Merit E Cudkowicz, et al.Science Translational Medicine|August 18, 2017
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative diseaseClaire E Le Pichon, William J Meilandt, Sara Dominguez, et al.Journal of Medicinal Chemistry|October 24, 2014
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration modelsSnahel Patel, Frederick Cohen, Brian J Dean, et al.Pageof 2