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Trials|August 2, 2018
Assessment of the effect of addition of 24 hours of oral tranexamic acid post-operatively to a single intraoperative intravenous dose of tranexamic acid on calculated blood loss following primary hip and knee arthroplasty (TRAC-24): a study protocol for a randomised controlled trialJanet Hill, Paul Magill, Alastair Dorman, et al.
Health Technology Assessment (Winchester, England)|March 15, 2022
Co-ordinated multidisciplinary intervention to reduce time to successful extubation for children on mechanical ventilation: the SANDWICH cluster stepped-wedge RCTBronagh Blackwood, Kevin P Morris, Joanne Jordan, et al.
JAMA|August 31, 2021
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical TrialJames J McNamee, Michael A Gillies, Nicholas A Barrett, et al.
Trials|December 21, 2019
A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trialJudy Martina Bradley, Rohan Anand, Brenda O'Neill, et al.
Thorax|July 9, 2025
Effect of simvastatin on postoperative complications in patients undergoing one-lung ventilation during surgery: the Prevention HARP-2 randomised controlled trialAdam Glass, Cecilia M O'Kane, Akesh Dhrampal, et al.
NIHR Open Research|June 16, 2025
Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilotBronwen Connolly, Naomi Dickson, Ashley Agus, et al.
The New England Journal of Medicine|June 10, 2026
Carbocisteine or Hypertonic Saline for Acute Respiratory FailureBronwen Connolly, Naomi Dickson, Christina Campbell, et al.
The New England Journal of Medicine|September 29, 2025
Hypertonic Saline or Carbocisteine in BronchiectasisJudy M Bradley, Brenda O'Neill, Daniel F McAuley, et al.
The Lancet. Respiratory Medicine|December 8, 2019
Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluationThomas P Hellyer, Daniel F McAuley, Timothy S Walsh, et al.
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