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Nature Structural & Molecular Biology|June 12, 2021
The structural basis of fatty acid elongation by the ELOVL elongasesLaiyin Nie, Tomas C Pascoa, Ashley C W Pike, et al.Structure (London, England : 1993)|May 30, 2024
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonistGamma Chi, Dawid Jaślan, Veronika Kudrina, et al.Nature Communications|May 16, 2024
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulationKarin E J Rödström, Alexander Cloake, Janina Sörmann, et al.Science (New York, N.Y.)|March 14, 2015
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with ProzacYin Yao Dong, Ashley C W Pike, Alexandra Mackenzie, et al.Nature|June 6, 2020
A lower X-gate in TASK channels traps inhibitors within the vestibuleKarin E J Rödström, Aytuğ K Kiper, Wei Zhang, et al.Nature Communications|July 1, 2024
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2Huanyu Z Li, Ashley C W Pike, Irina Lotsaris, et al.Proceedings of the National Academy of Sciences of the United States of America|May 30, 2013
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound statesChitra A Shintre, Ashley C W Pike, Qiuhong Li, et al.Science (New York, N.Y.)|February 23, 2019
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channelsMarcus Schewe, Han Sun, Ümit Mert, et al.Nature Communications|September 4, 2019
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16KSimon R Bushell, Ashley C W Pike, Maria E Falzone, et al.Nature Communications|January 17, 2025
Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2Huanyu Z Li, Ashley C W Pike, Yung-Ning Chang, et al.Pageof 5