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Scientific Reports|May 8, 2023
Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cellsMohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Essam Nageh Sholkamy, et al.
Bioorganic Chemistry|November 18, 2021
Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activatorsGehad Lotfy, Yasmine M Abdel Aziz, Mohamed M Said, et al.
Pharmaceuticals (Basel, Switzerland)|October 28, 2023
Synthesis and Biological Evaluation of Some New 3-Aryl-2-thioxo-2,3-dihydroquinazolin-4(1<i>H</i>)-ones and 3-Aryl-2-(benzylthio)quinazolin-4(3<i>H</i>)-ones as Antioxidants; COX-2, LDHA, α-Glucosidase and α-Amylase Inhibitors; and Anti-Colon Carcinoma and Apoptosis-Inducing AgentsNahed Nasser Eid El-Sayed, Taghreed M Al-Otaibi, Assem Barakat, et al.
Bioorganic Chemistry|September 29, 2022
Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinomaAssem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, et al.
Frontiers in Chemistry|October 15, 2024
Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell linesIhab Shawish, Samha Al Ayoubi, Ayman El-Faham, et al.
Journal of Enzyme Inhibition and Medicinal Chemistry|November 23, 2023
New spiro-indeno[1,2-<i>b</i>]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insightsAssem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, et al.
Molecules (Basel, Switzerland)|April 17, 2019
Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico StudyAbdullah Mohammed Al-Majid, Mohammad Shahidul Islam, Saleh Atef, et al.
ACS Omega|May 20, 2024
Triggering Breast Cancer Apoptosis via Cyclin-Dependent Kinase Inhibition and DNA Damage by Novel Pyrimidinone and 1,2,4-Triazolo[4,3-<i>a</i>]pyrimidinone DerivativesMohamed N Abd Al Moaty, Yeldez El Kilany, Laila F Awad, et al.
ACS Omega|July 29, 2024
Experimental and Computational Anticorrosion Behaviors of Pyrazole <i>s</i>-Triazine/anilino-morpholino Derivatives for Steel in Acidic SolutionsHassan H Hammud, Waleed A Aljamhi, Ihab Shawish, et al.
RSC Advances|January 7, 2025
Potent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapyMohamed S Nafie, M Ali, Moayad Abdullah Alwehaibi, et al.
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