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ACS Chemical Biology|May 15, 2019
PF-06651600, a Dual JAK3/TEC Family Kinase InhibitorHua Xu, Michael I Jesson, Uthpala I Seneviratne, et al.Bioorganic & Medicinal Chemistry Letters|May 2, 2012
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two watersJohn I Trujillo, James R Kiefer, Wei Huang, et al.Bioorganic & Medicinal Chemistry Letters|September 20, 2011
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffoldsMarvin J Meyers, Scott A Long, Matthew J Pelc, et al.ACS Chemical Biology|November 1, 2017
Microfluidic-Enabled Intracellular Delivery of Membrane Impermeable Inhibitors to Study Target Engagement in Human Primary CellsJing Li, Bu Wang, Brian M Juba, et al.Bioorganic & Medicinal Chemistry Letters|December 23, 2008
2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitorJohn I Trujillo, James R Kiefer, Wei Huang, et al.The Journal of Pharmacology and Experimental Therapeutics|April 16, 2010
A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammationJames Gierse, Atli Thorarensen, Konstantine Beltey, et al.Bioorganic & Medicinal Chemistry Letters|September 20, 2011
Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for painMarvin J Meyers, Scott A Long, Matthew J Pelc, et al.Bioorganic & Medicinal Chemistry Letters|February 9, 2010
Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding modeMarvin J Meyers, Matthew Pelc, Satwik Kamtekar, et al.Journal of Medicinal Chemistry|November 14, 2018
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent InhibitorsAgustin Casimiro-Garcia, John I Trujillo, Felix Vajdos, et al.Journal of Medicinal Chemistry|February 17, 2025
Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 AntagonistsBrian S Gerstenberger, Ray Unwalla, Kathleen A Farley, et al.Pageof 4