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Journal of Medicinal Chemistry|December 22, 2006
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activityMathew P Leese, Bertrand Leblond, Andrew Smith, et al.Molecular and Cellular Endocrinology|September 13, 2008
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3Joanna M Day, Helena J Tutill, Paul A Foster, et al.Chemmedchem|March 6, 2014
Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinonesMathew P Leese, Fabrice L Jourdan, Meriel R Major, et al.Chemmedchem|August 8, 2006
Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1Nigel Vicker, Harshani R Lawrence, Gillian M Allan, et al.Journal of Medicinal Chemistry|July 2, 2008
Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activityPaul M Wood, L W Lawrence Woo, Jean-Robert Labrosse, et al.Journal of Medicinal Chemistry|September 2, 2005
E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1Delphine S Fischer, Gillian M Allan, Christian Bubert, et al.Anticancer Research|May 30, 2008
A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancerPaul A Foster, Simon P Newman, Mathew P Leese, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|October 18, 2008
A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitorPaul A Foster, Surinder K Chander, Simon P Newman, et al.Journal of Medicinal Chemistry|August 19, 2007
3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activityChristian Bubert, Mathew P Leese, Mary F Mahon, et al.Chemmedchem|January 18, 2014
Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolinesWolfgang Dohle, Mathew P Leese, Fabrice L Jourdan, et al.Pageof 9