Showing results (1-10 of 11) with videos related to

Sort By:
Pageof 2
The AAPS Journal|August 13, 2025
Optimization of In Vitro CYP3A4 TDI Assay Conditions and Use of Derived Parameters for Clinical DDI Risk Assessment Using Static and Dynamic ModelsAlessandra Pugliano, Aynur Ekiciler, Lena Preiss, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 27, 2026
Combining the novel all-human co-cultured hepatocytes system with physiologically based pharmacokinetic modeling to assess the translatability of cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase induction dataAlessandra Pugliano, Aynur Ekiciler, Neil John Parrott, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 5, 2022
Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human HepatocytesFlorian Klammers, Andreas Goetschi, Aynur Ekiciler, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|December 2, 2022
Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating ProfilesAynur Ekiciler, Wen Li Kelly Chen, Yan Bo, et al.
The AAPS Journal|November 6, 2020
Correction to: In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human HepatocytesLuca Docci, Florian Klammers, Aynur Ekiciler, et al.
The AAPS Journal|October 14, 2020
In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human HepatocytesLuca Docci, Florian Klammers, Aynur Ekiciler, et al.
Scientific Reports|March 13, 2019
The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1Simone Schadt, Christophe Husser, Roland F Staack, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 3, 2020
Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance PredictionKenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 9, 2025
Prediction of hepatic metabolic clearance in rats and dogs using long-term cocultured hepatocytesKenichi Umehara, Florian Klammers, Isabelle Walter, et al.
The AAPS Journal|January 5, 2017
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects ModelingNicole A Kratochwil, Christophe Meille, Stephen Fowler, et al.
Pageof 2