Showing results (101-110 of 112) with videos related to
Sort By:
Pageof 12
Contemporary Clinical Trials Communications|April 25, 2019
A randomized pilot study comparing graft-first to fistula-first strategies in older patients with incident end-stage kidney disease: Clinical rationale and study designMariana Murea, Randolph L Geary, Matthew S Edwards, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing InteractionsJamison B Tuttle, Marie Anderson, Bruce M Bechle, et al.Cell Chemical Biology|September 30, 2020
Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoEUthpala Seneviratne, Zhen Huang, Christopher W Am Ende, et al.Nature Communications|September 23, 2023
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanismJoshua A Lees, João M Dias, Francis Rajamohan, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for SchizophreniaAmy B Dounay, Marie Anderson, Bruce M Bechle, et al.Journal of Medicinal Chemistry|January 8, 2014
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulatorLei Zhang, Gayatri Balan, Gabriela Barreiro, et al.Journal of Medicinal Chemistry|March 16, 2026
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled ReceptorEthan L Fisher, Anne-Marie Dechert Schmitt, Jamison B Tuttle, et al.Journal of Medicinal Chemistry|August 18, 2017
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman PrimatesAntonia F Stepan, Michelle M Claffey, Matthew R Reese, et al.Science (New York, N.Y.)|November 2, 2021
An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.Journal of Medicinal Chemistry|December 9, 2024
Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of CancerRebecca A Gallego, Sujin Cho-Schultz, Matthew Del Bel, et al.Pageof 12