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Journal of Bacteriology|May 11, 2016
De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In VivoEric M Kofoed, Donghong Yan, Anand K Katakam, et al.
Journal of the American Chemical Society|August 28, 2020
Streamlined Symmetrical Total Synthesis of Disorazole B1 and Design, Synthesis, and Biological Investigation of Disorazole AnaloguesK C Nicolaou, Johannes Krieger, Ganesh M Murhade, et al.
Journal of the American Chemical Society|July 15, 2020
Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug ConjugatesK C Nicolaou, Ruofan Li, Qifeng Chen, et al.
Cell|February 18, 2025
HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinitySkyler Y Blume, Ankur Garg, Yolanda Martí-Mateos, et al.
Bioorganic & Medicinal Chemistry Letters|October 31, 2020
Evaluation of PNU-159682 antibody drug conjugates (ADCs)Dane Holte, Joseph P Lyssikatos, Amanda M Valdiosera, et al.
Proceedings of the National Academy of Sciences of the United States of America|June 22, 2021
Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effectK C Nicolaou, Stephan Rigol, Emmanuel N Pitsinos, et al.
The Journal of Organic Chemistry|February 5, 2021
Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic AnalysisK C Nicolaou, Saiyong Pan, Kiran K Pulukuri, et al.
ACS Medicinal Chemistry Letters|December 30, 2015
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar MoietyChudi O Ndubaku, James J Crawford, Joy Drobnick, et al.
Science Translational Medicine|January 17, 2024
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disordersJulie C Ullman, Kevin T Mellem, Yannan Xi, et al.
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