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Bioorganic & Medicinal Chemistry Letters|January 15, 2014
Identification of a novel conformationally constrained glucagon receptor antagonistEsther C Y Lee, Meihua Tu, Benjamin D Stevens, et al.Bioorganic & Medicinal Chemistry Letters|November 29, 2011
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicityKevin J Filipski, Jianwei Bian, David C Ebner, et al.Bioorganic & Medicinal Chemistry Letters|April 9, 2013
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitusAngel Guzman-Perez, Jeffrey A Pfefferkorn, Esther C Y Lee, et al.Journal of Medicinal Chemistry|April 1, 2011
Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitorsVincent Mascitti, Tristan S Maurer, Ralph P Robinson, et al.Journal of Medicinal Chemistry|December 27, 2011
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitusJeffrey A Pfefferkorn, Angel Guzman-Perez, John Litchfield, et al.Pageof 2