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The EMBO Journal|October 17, 2025
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seedingFrancesca Simonetti, Weijia Zhong, Saskia Hutten, et al.Cell Reports|June 8, 2022
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTDMareike Czuppa, Ashutosh Dhingra, Qihui Zhou, et al.Proceedings of the National Academy of Sciences of the United States of America|March 5, 2013
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowthBettina Schmid, Alexander Hruscha, Sebastian Hogl, et al.Brain : a Journal of Neurology|February 28, 2026
Constitutive neuronal expression and disease-associated upregulation of chitinases in amyotrophic lateral sclerosisNayana Gaur, Christin Angerer, Zeynep I Gunes, et al.Acta Neuropathologica Communications|July 11, 2023
Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivoHenrick Riemenschneider, Francesca Simonetti, Udit Sheth, et al.EMBO Molecular Medicine|April 15, 2017
Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTDCarina Lehmer, Patrick Oeckl, Jochen H Weishaupt, et al.Translational Psychiatry|February 2, 2019
FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutationsJanine Diehl-Schmid, Abigail Licata, Oliver Goldhardt, et al.Nature Neuroscience|January 9, 2019
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoESamira Parhizkar, Thomas Arzberger, Matthias Brendel, et al.Nature Communications|April 11, 2025
Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 miceAli Rezaei, Virág Kocsis-Jutka, Zeynep I Gunes, et al.Acta Neuropathologica|October 7, 2015
Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72Marka van Blitterswijk, Tania F Gendron, Matthew C Baker, et al.Pageof 11