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Nature Communications|April 3, 2025
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVIDStefanie M Bader, Dale J Calleja, Shane M Devine, et al.Plos Pathogens|September 5, 2025
Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversityXinyu Wu, Shane M Devine, Margareta Go, et al.Elife|December 15, 2023
Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growthDaniel Frank, Maria Bergamasco, Michael J Mlodzianoski, et al.Nature Communications|July 23, 2024
Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escapeXinyu Wu, Margareta Go, Julie V Nguyen, et al.Plos Pathogens|July 16, 2020
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppressionLinda J Visser, Chiara Aloise, Kirby N Swatek, et al.Molecular Cell|February 18, 2018
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, et al.Nature Chemical Biology|May 17, 2016
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymesMonique P C Mulder, Katharina Witting, Ilana Berlin, et al.Cell|March 21, 2026
The E3-ome gene-centric compendium reveals the human E3 ligase landscapeNgee Kiat Chua, Tania J González-Robles, Cameron J Reddington, et al.The EMBO Journal|October 26, 2021
Oligomerization-driven MLKL ubiquitylation antagonizes necroptosisZikou Liu, Laura F Dagley, Kristy Shield-Artin, et al.Biochimica Et Biophysica Acta. General Subjects|October 3, 2020
The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathwayValentine Spagnol, Caio A B Oliveira, Suzanne J Randle, et al.Pageof 17