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Bioorganic & Medicinal Chemistry|November 26, 2005
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IVKarolina Ersmark, Martin Nervall, Hugo Gutiérrez-de-Terán, et al.Bioorganic & Medicinal Chemistry Letters|November 30, 2010
Design and synthesis of potent macrocyclic renin inhibitorsChristian Sund, Oscar Belda, Daniel Wiktelius, et al.Antimicrobial Agents and Chemotherapy|January 28, 2009
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitorTse-I Lin, Oliver Lenz, Gregory Fanning, et al.Journal of Medicinal Chemistry|January 23, 2014
Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitorÅsa Rosenquist, Bertil Samuelsson, Per-Ola Johansson, et al.Bioorganic & Medicinal Chemistry Letters|August 30, 2008
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitorsPierre Raboisson, Tse-I Lin, Herman de Kock, et al.Bioorganic & Medicinal Chemistry|September 12, 2007
Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifsMarcus Bäck, Per-Ola Johansson, Fredrik Wångsell, et al.European Journal of Biochemistry|April 16, 2003
Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitorsHans O Andersson, Kerstin Fridborg, Seved Löwgren, et al.Journal of Medicinal Chemistry|December 19, 2013
Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymeraseTim H M Jonckers, Koen Vandyck, Leen Vandekerckhove, et al.Antimicrobial Agents and Chemotherapy|May 18, 2011
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymeraseJan Martin Berke, Leen Vijgen, Sophie Lachau-Durand, et al.Bioorganic & Medicinal Chemistry Letters|June 15, 2010
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: exploration of P2 quinazoline substituentsMagnus Nilsson, Anna Karin Belfrage, Stefan Lindström, et al.Pageof 7