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The Journal of Biological Chemistry|July 15, 2003
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrinMatthew J LaVoie, Patrick C Fraering, Beth L Ostaszewski, et al.
Biochemistry|January 8, 2003
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s)W Taylor Kimberly, William P Esler, Wenjuan Ye, et al.
Neuron|April 2, 2014
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranesSoyon Hong, Beth L Ostaszewski, Ting Yang, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|November 4, 2011
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formationSoyon Hong, Omar Quintero-Monzon, Beth L Ostaszewski, et al.
Biochemistry|July 28, 2004
Purification and characterization of the human gamma-secretase complexPatrick C Fraering, Wenjuan Ye, Jean-Marc Strub, et al.
Biochemistry|May 21, 2014
Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticityAlfred T Welzel, John E Maggio, Ganesh M Shankar, et al.
Annals of Neurology|March 17, 2026
Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture MediaYi Ran Xu, Youqi Tao, Alexandra M Lish, et al.
Alzheimer'S Research & Therapy|July 11, 2025
An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levelsTing Yang, Yi Ran Xu, Shanxue Jin, et al.
Cell Reports|June 30, 2026
Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in miceTing Yang, Yi Ran Xu, Shaomin Li, et al.
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