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Bethany L Kormos

Showing results (21-30 of 29) with videos related to

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The Journal of Biological Chemistry|November 15, 2025
Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue modelRuth F Sommese, Samuel M Levi, Janice Brown, et al.
ACS Medicinal Chemistry Letters|February 20, 2018
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189Antonia F Stepan, Tuan P Tran, Christopher J Helal, et al.
Nature Communications|September 23, 2023
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanismJoshua A Lees, João M Dias, Francis Rajamohan, et al.
Journal of Medicinal Chemistry|June 3, 2017
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A InhibitorChristopher J Helal, Eric P Arnold, Tracey L Boyden, et al.
Journal of Medicinal Chemistry|March 17, 2012
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitorAntonia F Stepan, Chakrapani Subramanyam, Ivan V Efremov, et al.
Journal of Medicinal Chemistry|January 3, 2018
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical CandidateChristopher J Helal, Eric Arnold, Tracey Boyden, et al.
Nature Communications|August 9, 2023
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levelsRachel J Roth Flach, Eliza Bollinger, Allan R Reyes, et al.
Journal of Medicinal Chemistry|November 19, 2024
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948Kevin J Filipski, Luis A Martinez-Alsina, Matthew R Reese, et al.
Journal of Medicinal Chemistry|March 16, 2026
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled ReceptorEthan L Fisher, Anne-Marie Dechert Schmitt, Jamison B Tuttle, et al.
Pageof 3

Showing results (21-30 of 29) with videos related to

Sort By:
Pageof 3
You have reached the last page of results.This site can display upto 29 results.
The Journal of Biological Chemistry|November 15, 2025
Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue modelRuth F Sommese, Samuel M Levi, Janice Brown, et al.
ACS Medicinal Chemistry Letters|February 20, 2018
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189Antonia F Stepan, Tuan P Tran, Christopher J Helal, et al.
Nature Communications|September 23, 2023
An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanismJoshua A Lees, João M Dias, Francis Rajamohan, et al.
Journal of Medicinal Chemistry|June 3, 2017
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A InhibitorChristopher J Helal, Eric P Arnold, Tracey L Boyden, et al.
Journal of Medicinal Chemistry|March 17, 2012
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitorAntonia F Stepan, Chakrapani Subramanyam, Ivan V Efremov, et al.
Journal of Medicinal Chemistry|January 3, 2018
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical CandidateChristopher J Helal, Eric Arnold, Tracey Boyden, et al.
Nature Communications|August 9, 2023
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levelsRachel J Roth Flach, Eliza Bollinger, Allan R Reyes, et al.
Journal of Medicinal Chemistry|November 19, 2024
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948Kevin J Filipski, Luis A Martinez-Alsina, Matthew R Reese, et al.
Journal of Medicinal Chemistry|March 16, 2026
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled ReceptorEthan L Fisher, Anne-Marie Dechert Schmitt, Jamison B Tuttle, et al.
Pageof 3