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The Journal of Biological Chemistry|February 20, 2020
Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosisTravis B Lear, Karina C Lockwood, Mads Larsen, et al.Nature Communications|January 12, 2017
The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumoniaKrishnendu Chakraborty, Mahesh Raundhal, Bill B Chen, et al.Research Square|August 21, 2020
A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entryYanwen Chen, Travis B Lear, John W Evankovich, et al.Journal of Cell Science|November 26, 2015
LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1Chunbin Zou, Matthew J Synan, Jin Li, et al.Nature Communications|June 24, 2021
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entryYanwen Chen, Travis B Lear, John W Evankovich, et al.JCI Insight|June 5, 2020
Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1Yuan Liu, Travis B Lear, Manish Verma, et al.Nature Chemical Biology|January 26, 2021
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistanceYuan Liu, Michael J Jurczak, Travis B Lear, et al.The Journal of Clinical Investigation|April 15, 2025
A small-molecule inhibitor of BCL10-MALT1 interaction abrogates progression of diffuse large B cell lymphomaHeejae Kang, Lisa M Maurer, Jing Cheng, et al.Biorxiv : the Preprint Server for Biology|April 25, 2024
SON-dependent nuclear speckle rejuvenation alleviates proteinopathiesWilliam Dion, Yuren Tao, Maci Chambers, et al.Cell Reports|April 8, 2014
E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumoniaBill B Chen, Tiffany A Coon, Jennifer R Glasser, et al.Pageof 7