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Biorxiv : the Preprint Server for Biology|November 24, 2025
JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3Yao Yan, Guojun Shi, Kejiao Li, et al.
Cancers|December 9, 2023
POLD1 DEDD Motif Mutation Confers Hypermutation in Endometrial Cancer and Durable Response to PembrolizumabChristina Hsiao Wei, Edward Wenge Wang, Lingzi Ma, et al.
Nucleic Acids Research|August 1, 2023
FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stabilityWenpeng Liu, Piotr Polaczek, Ivan Roubal, et al.
Ebiomedicine|May 24, 2016
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to ChemotherapyWenpeng Liu, Mian Zhou, Zhengke Li, et al.
Journal for Immunotherapy of Cancer|April 5, 2024
Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancerAntons Martincuks, Chunyan Zhang, Theresa Austria, et al.
Cell|April 19, 2011
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamilySusan E Tsutakawa, Scott Classen, Brian R Chapados, et al.
Molecular Cell|May 20, 2014
CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activityHailong Wang, Yongjiang Li, Lan N Truong, et al.
BMC Cancer|April 18, 2015
YY1 suppresses FEN1 over-expression and drug resistance in breast cancerJianwei Wang, Lina Zhou, Zhi Li, et al.
ACS Chemical Biology|May 16, 2025
Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer TherapyYixing Wang, Jessica D Hess, Chen Wang, et al.
Iscience|March 30, 2026
New selective and allosteric FLT3 inhibitors show efficacy against resistant acute myeloid leukemia cellsShuai-Shuai Ge, Qiao-Cheng Qiu, Jingsheng Hua, et al.
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