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Malaria Journal|March 11, 2026
Integrative preclinical strategy for pharmacokinetic profiling and candidate selection of 3-hydroxypropanamidines: a promising antimalarial classAlena Moritz, Bastian Hirn-Derksen, Saskia Klein, et al.International Journal of Antimicrobial Agents|June 22, 2023
Quantification of Plasmodium falciparum HRP-2 as an alternative method to [3H]hypoxanthine incorporation to measure the parasite reduction ratio in vitroLaís Pessanha de Carvalho, Elena Niepoth, Arbreshe Mavraj-Husejni, et al.Pharmaceuticals (Basel, Switzerland)|August 26, 2022
Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp2)-H-HydroxylationAlexander Berger, Talea Knak, Anna-Lene Kiffe-Delf, et al.Frontiers in Pharmacology|January 11, 2021
Simulation Training to Improve Informed Consent and Pharmacokinetic/Pharmacodynamic Sampling in Pediatric TrialsBjoern B Burckhardt, Agnes Maria Ciplea, Anna Laven, et al.Pharmaceutics|June 24, 2022
Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)Stephanie Laeer, Willi Cawello, Bjoern B Burckhardt, et al.Journal of Medicinal Chemistry|March 5, 2021
3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparumTanja C Knaab, Jana Held, Bjoern B Burckhardt, et al.Journal of Medicinal Chemistry|May 6, 2026
Reverse Fosmidomycin Analogs as Bisubstrate Inhibitors: Binding Mode Elucidation and Mechanistic InsightsStefan Höfmann, Sana Takada, Boris Illarionov, et al.Journal of Medicinal Chemistry|September 8, 2025
Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial ActivitySaskia Klein, Alena Moritz, Lais Pessanha de Carvalho, et al.Journal of Medicinal Chemistry|June 18, 2025
Development and Characterization of the First Selective Class IIb Histone Deacetylase DegradersShiyang Zhai, Irina Honin, Linda Schäker-Hübner, et al.Journal of Medicinal Chemistry|December 26, 2024
TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to ResistanceTanja C Knaab, Alena Moritz, Lais Pessanha de Carvalho, et al.Pageof 6