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Journal of Medicinal Chemistry|May 3, 2021
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary FibrosisOscar Mammoliti, Adeline Palisse, Caroline Joannesse, et al.International Journal of Environmental Research and Public Health|August 26, 2022
Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease ResolutionAlexandre Soares Ferreira-Junior, Tais Fernanda Borgonovi, Larissa Vedovato Vilela De Salis, et al.Journal of Natural Products|December 3, 2024
In Vitro and In Vivo Leishmanicidal Activity of BeauvericinVirlânio A de Oliveira Filho, Juliana R Gubiani, Vitória D Borgonovi, et al.The European Respiratory Journal|December 17, 2021
Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunctionNiroop Kaza, Vivian Y Lin, Denise Stanford, et al.Bioorganic & Medicinal Chemistry|October 24, 2024
Design of a potent and selective dual JAK1/TYK2 inhibitorOscar Mammoliti, Christel Menet, Céline Cottereaux, et al.Journal of Medicinal Chemistry|November 18, 2017
Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High ExtentSteven E Van der Plas, Hans Kelgtermans, Tom De Munck, et al.Journal of Medicinal Chemistry|December 26, 2023
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312Taouès Temal-Laib, Christophe Peixoto, Nicolas Desroy, et al.Journal of Medicinal Chemistry|March 29, 2024
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory DiseasesChristophe Peixoto, Agnes Joncour, Taouès Temal-Laib, et al.Bioorganic & Medicinal Chemistry Letters|August 25, 2025
Discovery of GLPG4471, a potent and selective IRAK4 inhibitor for the treatment of inflammatory and autoimmune diseasesOscar Mammoliti, Florence Bonnaterre, Gregory Newsome, et al.Journal of Medicinal Chemistry|January 20, 2026
HBsAg Suppression by a New Series of HBV RNA Destabilizers: Discovery and Effects on In Vitro Neurite OutgrowthJacques Huck, Caroline Joannesse, Adeline Palisse, et al.Pageof 33