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Journal of Medicinal Chemistry|December 12, 2024
Discovery of VU6024578/BI02982816: An mGlu1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition ModelsCarson W Reed, Jacob F Kalbfleisch, Jeremy A Turkett, et al.
ACS Pharmacology & Translational Science|September 19, 2025
Highly Potent and Subtype-Selective Sperm-Specific Potassium Channel SLO3 Inhibitors Display High Tissue Exposure in the Murine Female Reproductive TractKayla J Temple, Ping Li, Hallie G McKinnie, et al.
Journal of Medicinal Chemistry|October 17, 2025
Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)Motoyuki Tanaka, Yoko Sekioka, Gakuji Hashimoto, et al.
ACS Medicinal Chemistry Letters|May 14, 2025
Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5Katherine E Crocker, Scott H Henderson, Rory A Capstick, et al.
Clinical Genetics|July 5, 2020
Fetal megacystis-microcolon: Genetic mutational spectrum and identification of PDCL3 as a novel candidate geneClarisse Billon, Arnaud Molin, Céline Poirsier, et al.
ACS Chemical Neuroscience|January 25, 2026
Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo EfficacyAlison R Gregro, Charlotte Park, Madeline F Long, et al.
JACC. Basic to Translational Science|July 3, 2020
Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by HypertensionJoseph K Prinsen, Prince J Kannankeril, Tatiana N Sidorova, et al.
ACS Chemical Neuroscience|December 11, 2024
Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical TrialsMichael S Poslunsey, Michael R Wood, Changho Han, et al.
ACS Chemical Neuroscience|July 16, 2026
Discovery of VU6081679, a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 8 with Efficacy in a Preclinical Model of Parkinson's DiseaseAlexa E Richardson, Anthony S Ferranti, Li Peng, et al.
ACS Chemical Neuroscience|June 6, 2026
Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition ModelCaleb A Jones, Renn A Duncan, Kristen M Gilliland, et al.
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