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Cell Reports|September 8, 2021
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic nicheXi He, Sarah E Smith, Shiyuan Chen, et al.Journal of Medicinal Chemistry|May 10, 2017
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic InhibitorsWilliam McCoull, Roman D Abrams, Erica Anderson, et al.Journal of Medicinal Chemistry|May 21, 2020
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse ModelChristophe Fromont, Alessio Atzori, Divneet Kaur, et al.Journal of Medicinal Chemistry|May 12, 2016
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)James D Osborne, Thomas P Matthews, Tatiana McHardy, et al.Nature Medicine|December 22, 2025
Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trialJohn R P Tesser, Angela R Crowley, Emily Jane Box, et al.Journal of Medicinal Chemistry|April 7, 2023
Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic QuinolinonesAlice C Harnden, Owen A Davis, Gary M Box, et al.Proteins|October 9, 2025
Protein Target Highlights in CASP16: Insights From the Structure ProvidersLeila T Alexander, Océane M Follonier, Andriy Kryshtafovych, et al.Oncoimmunology|December 19, 2024
Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conferencePierre-Antoine Laurent, Fabrice André, Alexandre Bobard, et al.Journal of Medicinal Chemistry|April 11, 2020
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 DegradersBenjamin R Bellenie, Kwai-Ming J Cheung, Ana Varela, et al.Medrxiv : the Preprint Server for Health Sciences|November 24, 2025
Enhanced HIV-1 Control After Antibody Therapy is Associated with Autologous Antibodies and Reservoir Clearance in the RIO trialMarcilio J Fumagalli, Anna Kaczynska, Marius Allombert, et al.Pageof 117