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Current Drug Metabolism|October 9, 2002
Complexities of glucuronidation affecting in vitro in vivo extrapolationJiunn H Lin, Bradley K WongXenobiotica; the Fate of Foreign Compounds in Biological Systems|March 10, 2016
Single concentration loss of activity assay provides an improved assessment of drug-drug interaction risk compared to IC50-shiftSimon G Wong, Mey Lee, Bradley K WongJournal of Pharmaceutical and Biomedical Analysis|July 19, 2005
In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanideC Charles Lin, Bradley K Wong, Christopher S Burgey, et al.Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences|January 30, 2008
A fully automated plasma protein precipitation sample preparation method for LC-MS/MS bioanalysisJi Ma, Jianxia Shi, Hoa Le, et al.The Journal of Pharmacology and Experimental Therapeutics|August 8, 2012
Deletion of Abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in ratsLiyue Huang, Xuhai Be, Eskouhie H Tchaparian, et al.Xenobiotica; the Fate of Foreign Compounds in Biological Systems|March 24, 2015
Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlationQiuping Ye, Min Jiang, Wotang T Huang, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|January 27, 2010
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interactionSimon G Wong, Peter W Fan, Raju Subramanian, et al.Chemical Research in Toxicology|February 18, 2003
Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteinsRominder Singh, Maria V Silva Elipe, Paul G Pearson, et al.Journal of Medicinal Chemistry|October 4, 2002
Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicityStephen F Brady, Joseph M Pawluczyk, Patricia K Lumma, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 21, 2012
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzymeKirk R Henne, Thuy B Tran, Brooke M VandenBrink, et al.Pageof 3