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The Journal of Biological Chemistry|May 23, 2015
Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and InvasivenessNicholas Artinian, Cheri Cloninger, Brent Holmes, et al.International Journal of Molecular Sciences|January 18, 2020
Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant GlioblastomaAngelica Benavides-Serrato, Jacquelyn T Saunders, Brent Holmes, et al.Neoplasia (New York, N.Y.)|August 3, 2021
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristicsBrent Holmes, Angelica Benavides-Serrato, Jacquelyn T Saunders, et al.Genes & Cancer|January 9, 2015
mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastomaAngelica Benavides-Serrato, Lauren Anderson, Brent Holmes, et al.Journal of Neuro-Oncology|January 29, 2021
Targeting the YAP-TEAD interaction interface for therapeutic intervention in glioblastomaJacquelyn T Saunders, Brent Holmes, Angelica Benavides-Serrato, et al.Molecular Cancer Therapeutics|January 28, 2022
Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple MyelomaYijiang Shi, Fumou Sun, Yan Cheng, et al.Molecular Cancer Research : MCR|December 8, 2010
AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradationRaffi Vartanian, Janine Masri, Jheralyn Martin, et al.The Journal of Biological Chemistry|May 27, 2016
Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat GlioblastomaBrent Holmes, Jihye Lee, Kenna A Landon, et al.Journal of Neuro-Oncology|September 2, 2019
The protein arginine methyltransferase PRMT5 confers therapeutic resistance to mTOR inhibition in glioblastomaBrent Holmes, Angelica Benavides-Serrato, Jacquelyn T Saunders, et al.Plos One|February 7, 2019
Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastomaAngelica Benavides-Serrato, Jihye Lee, Brent Holmes, et al.Pageof 2