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Bioorganic & Medicinal Chemistry Letters|January 3, 2012
SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonistXianhai Huang, Jing Su, Ashwin U Rao, et al.Bioorganic & Medicinal Chemistry Letters|October 6, 2009
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonistsJack D Scott, Michael W Miller, Sarah W Li, et al.Journal of Medicinal Chemistry|January 2, 2010
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitorsYu-Sen Wang, Corey Strickland, Johannes H Voigt, et al.Journal of Medicinal Chemistry|January 2, 2010
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validationZhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, et al.Bioorganic & Medicinal Chemistry Letters|June 29, 2010
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesisElizabeth M Smith, Steve Sorota, Hyunjin M Kim, et al.Bioorganic & Medicinal Chemistry Letters|March 7, 2012
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitorJared N Cumming, Elizabeth M Smith, Lingyan Wang, et al.Bioorganic & Medicinal Chemistry Letters|October 24, 2006
2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitorsDmitri A Pissarnitski, Theodros Asberom, Thomas A Bara, et al.Journal of Medicinal Chemistry|September 20, 2012
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformationMihirbaran Mandal, Zhaoning Zhu, Jared N Cumming, et al.ACS Medicinal Chemistry Letters|February 16, 2013
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aβ ReductionAndrew W Stamford, Jack D Scott, Sarah W Li, et al.Bioorganic & Medicinal Chemistry Letters|March 3, 2015
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitorsBrian A McKittrick, John P Caldwell, Thomas Bara, et al.Pageof 3