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Science (New York, N.Y.)|May 16, 2024
AlphaFold2 structures guide prospective ligand discoveryJiankun Lyu, Nicholas Kapolka, Ryan Gumpper, et al.Neuron|September 10, 2022
Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSDCan Cao, Ximena Barros-Álvarez, Shicheng Zhang, et al.Proceedings of the National Academy of Sciences of the United States of America|June 2, 2016
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activationPeter M Grace, Keith A Strand, Erika L Galer, et al.Science (New York, N.Y.)|March 23, 2013
Structural basis for molecular recognition at serotonin receptorsChong Wang, Yi Jiang, Jinming Ma, et al.Biorxiv : the Preprint Server for Biology|October 9, 2023
A suite of engineered mice for interrogating psychedelic drug actionsYi-Ting Chiu, Ariel Y Deutch, Wei Wang, et al.Nature Communications|August 5, 2024
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated stateKevin M Knight, Brian E Krumm, Nicholas J Kapolka, et al.Cell|December 4, 2024
Structure-guided design of a peripherally restricted chemogenetic systemHye Jin Kang, Brian E Krumm, Adrien Tassou, et al.Nature|December 14, 2012
Automated design of ligands to polypharmacological profilesJérémy Besnard, Gian Filippo Ruda, Vincent Setola, et al.ACS Chemical Biology|April 26, 2013
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1Kyle D Konze, Anqi Ma, Fengling Li, et al.Neuron|July 19, 2025
The polypharmacology of psychedelics reveals multiple targets for potential therapeuticsManish K Jain, Ryan H Gumpper, Samuel T Slocum, et al.Pageof 43