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Journal of Medicinal Chemistry
|
October 26, 2012
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
Paul V Fish, Panagis Filippakopoulos, Gerwyn Bish, et al.
Science Advances
|
December 25, 2015
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
Oleg Fedorov, Josefina Castex, Cynthia Tallant, et al.
Journal of Medicinal Chemistry
|
February 17, 2025
Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists
Brian S Gerstenberger, Ray Unwalla, Kathleen A Farley, et al.
Bioorganic & Medicinal Chemistry
|
April 8, 2020
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1
Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.
Journal of Medicinal Chemistry
|
August 14, 2020
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Brian S Gerstenberger, Catherine Ambler, Eric P Arnold, et al.
ACS Chemical Biology
|
August 30, 2017
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation
Julia C Meier, Cynthia Tallant, Oleg Fedorov, et al.
Journal of Medicinal Chemistry
|
April 27, 2016
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit
Brian S Gerstenberger, John D Trzupek, Cynthia Tallant, et al.
Nature Communications
|
August 31, 2024
Structural basis for CCR6 modulation by allosteric antagonists
David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, et al.
Journal of Medicinal Chemistry
|
August 17, 2018
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.
Journal of Medicinal Chemistry
|
June 13, 2013
Pyridone-conjugated monobactam antibiotics with gram-negative activity
Matthew F Brown, Mark J Mitton-Fry, Joel T Arcari, et al.
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of 3
Search research articles
Search
Showing results (11-20 of 24) with videos related to
Sort By:
Page
of 3
Journal of Medicinal Chemistry
|
October 26, 2012
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
Paul V Fish, Panagis Filippakopoulos, Gerwyn Bish, et al.
Science Advances
|
December 25, 2015
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
Oleg Fedorov, Josefina Castex, Cynthia Tallant, et al.
Journal of Medicinal Chemistry
|
February 17, 2025
Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists
Brian S Gerstenberger, Ray Unwalla, Kathleen A Farley, et al.
Bioorganic & Medicinal Chemistry
|
April 8, 2020
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1
Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.
Journal of Medicinal Chemistry
|
August 14, 2020
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Brian S Gerstenberger, Catherine Ambler, Eric P Arnold, et al.
ACS Chemical Biology
|
August 30, 2017
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation
Julia C Meier, Cynthia Tallant, Oleg Fedorov, et al.
Journal of Medicinal Chemistry
|
April 27, 2016
Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit
Brian S Gerstenberger, John D Trzupek, Cynthia Tallant, et al.
Nature Communications
|
August 31, 2024
Structural basis for CCR6 modulation by allosteric antagonists
David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, et al.
Journal of Medicinal Chemistry
|
August 17, 2018
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.
Journal of Medicinal Chemistry
|
June 13, 2013
Pyridone-conjugated monobactam antibiotics with gram-negative activity
Matthew F Brown, Mark J Mitton-Fry, Joel T Arcari, et al.
Page
of 3