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Journal of Medicinal Chemistry|April 4, 2019
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na<sub>v</sub>1.7 Inhibitors for the Treatment of Chronic PainSteven J McKerrall, Teresa Nguyen, Kwong Wah Lai, et al.Science (New York, N.Y.)|December 19, 2015
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonistShivani Ahuja, Susmith Mukund, Lunbin Deng, et al.Bioorganic & Medicinal Chemistry Letters|November 23, 2024
Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of Na<sub>V</sub>1.7Shaoyi Sun, Sultan Chowdhury, Ivan Hemeon, et al.Nature Cancer|February 5, 2022
Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunityShelley E Ackerman, Cecelia I Pearson, Joshua D Gregorio, et al.Journal of Medicinal Chemistry|March 22, 2021
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron MicroscopyJack A Terrett, Huifen Chen, Daniel G Shore, et al.Journal of Medicinal Chemistry|December 1, 2018
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na<sub>V</sub>) 1.7 with Potent Analgesic ActivityShaoyi Sun, Qi Jia, Alla Y Zenova, et al.Journal of Medicinal Chemistry|May 9, 2018
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa<sub>V</sub>1.7 Inhibitors for the Treatment of PainThilo Focken, Sultan Chowdhury, Alla Zenova, et al.Journal of Medicinal Chemistry|March 8, 2021
Discovery of Acyl-sulfonamide Na<sub>v</sub>1.7 Inhibitors GDC-0276 and GDC-0310Brian S Safina, Steven J McKerrall, Shaoyi Sun, et al.Journal of Medicinal Chemistry|May 26, 2012
Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibitionBrian S Safina, Stewart Baker, Matt Baumgardner, et al.Journal of Medicinal Chemistry|March 3, 2024
Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory DiseaseJack A Terrett, Justin Q Ly, Paula Katavolos, et al.Pageof 3