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Brian W Dymock

Showing results (31-40 of 45) with videos related to

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Bioorganic & Medicinal Chemistry Letters|May 18, 2012
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screeningAngeline C-H Lee, Pondy Murugappan Ramanujulu, Anders Poulsen, et al.
Bioorganic & Medicinal Chemistry Letters|February 17, 2006
4-Amino derivatives of the Hsp90 inhibitor CCT018159Xavier Barril, Mandy C Beswick, Adam Collier, et al.
Journal of Medicinal Chemistry|June 25, 2005
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based designBrian W Dymock, Xavier Barril, Paul A Brough, et al.
Journal of Medicinal Chemistry|September 28, 2017
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and VorinostatLianbin Yao, Nurulhuda Mustafa, Eng Chong Tan, et al.
Experimental Cell Research|July 1, 2018
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signallingKwi Shan Seah, Jian Yun Loh, Thi Thuy Trang Nguyen, et al.
Antioxidants & Redox Signaling|October 8, 2013
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegansBedoor Qabazard, Ling Li, Jan Gruber, et al.
Bioorganic & Medicinal Chemistry Letters|March 23, 2012
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1Stéphanie Blanchard, Chang Kai Soh, Chai Ping Lee, et al.
Bioorganic & Medicinal Chemistry Letters|November 13, 2003
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activityKevin R Guertin, Lina Setti, Lida Qi, et al.
Journal of Medicinal Chemistry|February 21, 2012
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritisAnthony D William, Angeline C-H Lee, Anders Poulsen, et al.
Journal of Medicinal Chemistry|December 14, 2011
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancerAnthony D William, Angeline C-H Lee, Kee Chuan Goh, et al.
Pageof 5

Showing results (31-40 of 45) with videos related to

Sort By:
Pageof 5
Bioorganic & Medicinal Chemistry Letters|May 18, 2012
Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screeningAngeline C-H Lee, Pondy Murugappan Ramanujulu, Anders Poulsen, et al.
Bioorganic & Medicinal Chemistry Letters|February 17, 2006
4-Amino derivatives of the Hsp90 inhibitor CCT018159Xavier Barril, Mandy C Beswick, Adam Collier, et al.
Journal of Medicinal Chemistry|June 25, 2005
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based designBrian W Dymock, Xavier Barril, Paul A Brough, et al.
Journal of Medicinal Chemistry|September 28, 2017
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and VorinostatLianbin Yao, Nurulhuda Mustafa, Eng Chong Tan, et al.
Experimental Cell Research|July 1, 2018
SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signallingKwi Shan Seah, Jian Yun Loh, Thi Thuy Trang Nguyen, et al.
Antioxidants & Redox Signaling|October 8, 2013
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegansBedoor Qabazard, Ling Li, Jan Gruber, et al.
Bioorganic & Medicinal Chemistry Letters|March 23, 2012
2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1Stéphanie Blanchard, Chang Kai Soh, Chai Ping Lee, et al.
Bioorganic & Medicinal Chemistry Letters|November 13, 2003
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activityKevin R Guertin, Lina Setti, Lida Qi, et al.
Journal of Medicinal Chemistry|February 21, 2012
Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arthritisAnthony D William, Angeline C-H Lee, Anders Poulsen, et al.
Journal of Medicinal Chemistry|December 14, 2011
Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kinases (CDKs), Janus kinase 2 (JAK2), and fms-like tyrosine kinase-3 (FLT3) for the treatment of cancerAnthony D William, Angeline C-H Lee, Kee Chuan Goh, et al.
Pageof 5