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Drug Discovery Today|May 2, 2017
Targeting isocitrate lyase for the treatment of latent tuberculosisRam Prasad Bhusal, Ghader Bashiri, Brooke X C Kwai, et al.
Chembiochem : a European Journal of Chemical Biology|May 21, 2023
Mycobacterium tuberculosis Rv1916 is an Acetyl-CoA-Binding ProteinEvelyn Yu-Wen Huang, Brooke X C Kwai, Ram Prasad Bhusal, et al.
RSC Medicinal Chemistry|May 28, 2021
Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyaseBrooke X C Kwai, Annabelle J Collins, Martin J Middleditch, et al.
Medchemcomm|August 16, 2018
Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitorsRam Prasad Bhusal, Krunal Patel, Brooke X C Kwai, et al.
Nature Communications|October 13, 2019
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2Ram Prasad Bhusal, Wanting Jiao, Brooke X C Kwai, et al.
Communications Biology|March 10, 2026
Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2Evelyn Yu-Wen Huang, Brooke X C Kwai, Wanting Jiao, et al.
ACS Chemical Biology|November 17, 2025
NMR and SPR Fragment-Based Screening Can Produce Novel High Affinity Small Molecule Hits against Structured RNAsBrooke X C Kwai, Indu R Chandrashekaran, Biswaranjan Mohanty, et al.
QRB Discovery|May 21, 2025
An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosisEvelyn Y-W Huang, Francis Kuang, Haozhe Wu, et al.
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