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Bioorganic & Medicinal Chemistry Letters|May 18, 2016
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreMichael R Wood, Meredith J Noetzel, Julie L Engers, et al.ACS Chemical Neuroscience|December 11, 2024
Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical TrialsMichael S Poslunsey, Michael R Wood, Changho Han, et al.Bioorganic & Medicinal Chemistry Letters|June 29, 2019
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMsTrevor C Chopko, Changho Han, Alison R Gregro, et al.ACS Chemical Neuroscience|June 6, 2026
Discovery of VU6053371/BI03738809: A First-in-Class Selective and CNS-Penetrant mGlu3 Positive Allosteric Modulator (PAM) with Efficacy in a Preclinical Cognition ModelCaleb A Jones, Renn A Duncan, Kristen M Gilliland, et al.Pageof 5