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Molecular Cell|March 4, 2022
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complexSotirios D Zervopoulos, Aristeidis E Boukouris, Bruno Saleme, et al.
Science Translational Medicine|February 8, 2019
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicityBruno Saleme, Vikram Gurtu, Yongneng Zhang, et al.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)|March 8, 2024
The Effects of Oxygen-Derived Free-Radical Scavengers During Normothermic Ex-Situ Heart PerfusionXiao Qi, Sanaz Hatami, Sabin Bozso, et al.
Journal of Molecular Medicine (Berlin, Germany)|July 30, 2020
Interaction with p53 explains a pro-proliferative function for VHL in cancerAdam Kinnaird, Aristeidis E Boukouris, Bruno Saleme, et al.
American Journal of Physiology. Heart and Circulatory Physiology|July 9, 2017
FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expressionKeshav Gopal, Bruno Saleme, Rami Al Batran, et al.
Journal of the American Heart Association|November 1, 2021
SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both GenesYongneng Zhang, Sotirios D Zervopoulos, Aristeidis E Boukouris, et al.
JCI Insight|January 11, 2019
The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activityRami Al Batran, Keshav Gopal, Hanin Aburasayn, et al.
European Urology|October 5, 2015
Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase KinaseAdam Kinnaird, Peter Dromparis, Bruno Saleme, et al.
Science Translational Medicine|November 2, 2022
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failureMaria Areli Lorenzana-Carrillo, Keshav Gopal, Nikole J Byrne, et al.
Cell Reports|March 16, 2022
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancerAristeidis E Boukouris, Yongneng Zhang, Bruno Saleme, et al.
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