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Journal of Medicinal Chemistry|February 9, 2016
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase InhibitorsPhilip A Harris, Bryan W King, Deepak Bandyopadhyay, et al.Journal of Medicinal Chemistry|July 3, 2019
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[<i>d</i>]thiazol-5-ylamino)-6-(<i>tert</i>-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory DiseasesPamela A Haile, Linda N Casillas, Bartholomew J Votta, et al.Journal of Medicinal Chemistry|April 26, 2016
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 KinasePamela A Haile, Bartholomew J Votta, Robert W Marquis, et al.Journal of Medicinal Chemistry|February 3, 2017
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory DiseasesPhilip A Harris, Scott B Berger, Jae U Jeong, et al.Journal of Medicinal Chemistry|April 24, 2019
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) KinasePhilip A Harris, Nicolas Faucher, Nicolas George, et al.Nature Cancer|November 18, 2021
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemiaMelissa B Pappalardi, Kathryn Keenan, Mark Cockerill, et al.Nature Communications|July 14, 2018
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screeningCarl A Machutta, Christopher S Kollmann, Kenneth E Lind, et al.Nature Communications|July 18, 2017
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screeningCarl A Machutta, Christopher S Kollmann, Kenneth E Lind, et al.Pageof 2