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ACS Medicinal Chemistry Letters|June 18, 2025
Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain BindersJeffrey A Boerth, Marianne Schimpl, Simon C C Lucas, et al.RSC Medicinal Chemistry|December 22, 2022
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinatesS Paul Jones, James D Firth, Mary C Wheldon, et al.Journal of Medicinal Chemistry|July 13, 2026
X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1)Xinyu Wang, William T W Butler, James R Donald, et al.SLAS Discovery : Advancing Life Sciences R & D|December 26, 2019
Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain InteractionsAlexander N Phillipou, Charles S Lay, Charlotte E Carver, et al.Journal of Medicinal Chemistry|July 14, 2021
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) InhibitorsSimon C C Lucas, Stephen J Atkinson, Chun-Wa Chung, et al.Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology|October 14, 2000
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant gliomaH S Friedman, J Pluda, J A Quinn, et al.Journal of Medicinal Chemistry|March 21, 2024
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional DegradersSimon C C Lucas, Afshan Ahmed, S Neha Ashraf, et al.Clinical Pharmacology and Therapeutics|March 7, 2007
The pharmacogenetics research network: from SNP discovery to clinical drug responseK M Giacomini, C M Brett, R B Altman, et al.Journal of Medicinal Chemistry|August 10, 2019
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit QualificationPaul Bamborough, Chun-Wa Chung, Emmanuel H Demont, et al.Journal of Medicinal Chemistry|June 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, et al.Pageof 14