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Drug Metabolism and Disposition: the Biological Fate of Chemicals|November 3, 2020
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk AssessmentSimon G Wong, Diane Ramsden, Shannon Dallas, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 14, 2022
The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in HumansJonathan N Bauman, Angela C Doran, Amanda King-Ahmad, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems|May 2, 2013
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alphaAmit S Kalgutkar, Danny Chen, Manthena V Varma, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 1, 2018
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical RelevanceJane R Kenny, Diane Ramsden, David B Buckley, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 11, 2026
In vitro reversible enzyme inhibition assays to predict drug-drug interactions: Current state and industry perspective from the IQ Consortium Enzyme Inhibition Working GroupCarlo Sensenhauser, Sarah M Glass, Upendra P Dahal, et al.
Medchemcomm|August 16, 2018
Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profileK Futatsugi, K Huard, D W Kung, et al.
Journal of Medicinal Chemistry|September 9, 2015
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)Kentaro Futatsugi, Daniel W Kung, Suvi T M Orr, et al.
Bioorganic & Medicinal Chemistry Letters|December 25, 2010
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distributionJeffrey A Pfefferkorn, John Litchfield, Richard Hutchings, et al.
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