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Bioorganic & Medicinal Chemistry|January 1, 1996
The design of dipeptide helical mimetics: the synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanesD C Horwell, W Howson, G S Ratcliffe, et al.Bioorganic & Medicinal Chemistry Letters|March 14, 2000
Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIAS Menzler, J A Bikker, N Suman-Chauhan, et al.Neuropeptides|July 1, 1991
Studies on the effect of systemic PD134308 (CAM 958) in spinal reflex and pain models with special reference to interaction with morphine and intrathecal galaninZ Wiesenfeld-Hallin, X J Xu, J Hughes, et al.Proceedings of the National Academy of Sciences of the United States of America|September 1, 1990
PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexesZ Wiesenfeld-Hallin, X J Xu, J Hughes, et al.British Journal of Pharmacology|March 1, 1992
CI988, a selective antagonist of cholecystokininB receptors, prevents morphine tolerance in the ratX J Xu, Z Wiesenfeld-Hallin, J Hughes, et al.Journal of Medicinal Chemistry|October 27, 1995
Quantitative structure-activity relationships (QSARs) of N-terminus fragments of NK1 tachykinin antagonists: a comparison of classical QSARs and three-dimensional QSARs from similarity matricesD C Horwell, W Howson, M Higginbottom, et al.Journal of Medicinal Chemistry|January 1, 1990
Highly selective kappa-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivativesP R Halfpenny, D C Horwell, J Hughes, et al.Bioorganic & Medicinal Chemistry Letters|September 7, 1999
Synthesis and biological evaluation of conformationally restricted Gabapentin analoguesJ M Receveur, J S Bryans, M J Field, et al.Bioorganic & Medicinal Chemistry|July 10, 1999
An in vitro investigation into conformational aspects of gabapentinJ S Bryans, D C Horwell, G S Ratcliffe, et al.Bioorganic & Medicinal Chemistry|September 1, 1993
Conformationally restricted analogues of the potent CCK-B antagonist CI-988M Higginbottom, D R Hill, D C Horwell, et al.Pageof 5