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Cancer Research|December 1, 1993
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomesT K Chang, G F Weber, C L Crespi, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|August 1, 1997
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activationE L Code, C L Crespi, B W Penman, et al.
Cancer Research|June 1, 1993
Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustardT K Chang, D J Waxman
Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 29, 1999
Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profilesP Roy, L J Yu, C L Crespi, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 1, 1994
1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) modulates rat liver microsomal cyclophosphamide and ifosphamide activation by suppressing cytochrome P450 2C11 messenger RNA levelsT K Chang, H Chen, D J Waxman
The Journal of Pharmacology and Experimental Therapeutics|July 1, 1995
Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolismT K Chang, G Chen, D J Waxman
Archives of Biochemistry and Biophysics|June 1, 1994
Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450T K Chang, F J Gonzalez, D J Waxman
Cancer Research|May 15, 1997
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorinesT K Chang, L Yu, P Maurel, et al.
The Biochemical Journal|April 15, 1993
The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylationT K Chang, J Teixeira, G Gil, et al.
Pharmacogenetics|June 1, 1997
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activationT K Chang, L Yu, J A Goldstein, et al.
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