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Pharmacological Research|February 22, 2022
ABCB1 limits brain exposure of the KRAS<sup>G12C</sup> inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availabilityNancy H C Loos, Irene A Retmana, Wenlong Li, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|August 16, 2023
Pharmacokinetics of the KRAS<sup>G12C</sup> inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1cNancy H C Loos, Irene A Retmana, Jamie Rijmers, et al.
Arthritis Research & Therapy|September 26, 2012
Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatmentMaria C Lebre, Christina L Jonckheere, Maarten C Kraan, et al.
Plos One|July 13, 2011
Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritisMaria C Lebre, Clarissa E Vergunst, Ivy Y K Choi, et al.
Molecular Pharmaceutics|September 23, 2024
Brain Exposure to the Macrocyclic ALK Inhibitor Zotizalkib is Restricted by ABCB1, and Its Plasma Disposition is Affected by Mouse Carboxylesterase 1cJamie Rijmers, Rolf W Sparidans, Manon Acda, et al.
Molecular Pharmaceutics|November 3, 2021
P-Glycoprotein (ABCB1/MDR1) Controls Brain Penetration and Intestinal Disposition of the PARP1/2 Inhibitor NiraparibMargarida L F Martins, Nancy H C Loos, Sümeyra Mucuk, et al.
Arthritis Research & Therapy|August 23, 2014
Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?Lisa G M van Baarsen, Maria C Lebre, Dennis van der Coelen, et al.
The Journal of Investigative Dermatology|October 28, 2006
Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9Maria C Lebre, Angelic M G van der Aar, Lisa van Baarsen, et al.
Pharmaceutical Research|June 21, 2023
P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in MiceMargarida L F Martins, Nancy H C Loos, Malika El Yattouti, et al.
Rheumatology (Oxford, England)|May 15, 2016
Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapyMaria I Ramos, Marcel B M Teunissen, Boy Helder, et al.
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