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Journal of Medicinal Chemistry|March 18, 2015
Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine CarbapenemasesScott J Hecker, K Raja Reddy, Maxim Totrov, et al.Blood|November 14, 2022
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenograftsDeyi Zhang, Hailey M Harris, Jonathan Chen, et al.Plos One|February 6, 2013
Combining functional and structural genomics to sample the essential Burkholderia structomeLoren Baugh, Larry A Gallagher, Rapatbhorn Patrapuvich, et al.Journal of Medicinal Chemistry|February 1, 2024
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell MalignanciesDaniel W Robbins, Mark A Noviski, Ying Siow Tan, et al.Tuberculosis (Edinburgh, Scotland)|January 24, 2015
Increasing the structural coverage of tuberculosis drug targetsLoren Baugh, Isabelle Phan, Darren W Begley, et al.Science (New York, N.Y.)|July 4, 2024
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin inductionPamela Y Ting, Sneha Borikar, John Ryan Kerrigan, et al.Cell Chemical Biology|March 2, 2023
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapySimone Bonazzi, Eva d'Hennezel, Rohan E J Beckwith, et al.Pageof 20