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Journal of Cachexia, Sarcopenia and Muscle|May 13, 2026
Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti-GDF-15 Antibody-Based Combination TherapiesDanna M Breen, Stephanie Joaquim, Brianna LaCarubba Paulhus, et al.Cell Reports|January 14, 2023
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexiaJa Young Kim-Muller, LouJin Song, Brianna LaCarubba Paulhus, et al.The Journal of Biological Chemistry|November 15, 2025
Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue modelRuth F Sommese, Samuel M Levi, Janice Brown, et al.Molecular Metabolism|October 11, 2022
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in miceEliza Bollinger, Matthew Peloquin, Jenna Libera, et al.Kidney International|May 23, 2025
Restoration of branched chain amino acid catabolism improves kidney function in preclinical cardiovascular-kidney-metabolic syndrome modelsEliza Bollinger, George Williams, Mary E Piper, et al.Nature Communications|August 9, 2023
Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levelsRachel J Roth Flach, Eliza Bollinger, Allan R Reyes, et al.Journal of Affective Disorders|February 5, 2023
Single-dose psilocybin for a treatment-resistant episode of major depression: Impact on patient-reported depression severity, anxiety, function, and quality of lifeGuy M Goodwin, Scott T Aaronson, Oscar Alvarez, et al.Journal of Medicinal Chemistry|November 19, 2024
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948Kevin J Filipski, Luis A Martinez-Alsina, Matthew R Reese, et al.The New England Journal of Medicine|November 2, 2022
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major DepressionGuy M Goodwin, Scott T Aaronson, Oscar Alvarez, et al.Pageof 4