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Journal of Medicinal Chemistry|February 22, 2011
Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitorsNoel D D'Angelo, Tae-Seong Kim, Kristin Andrews, et al.ACS Medicinal Chemistry Letters|February 21, 2015
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular LiabilitiesYuan Cheng, James Brown, Ted C Judd, et al.Nature|November 15, 2013
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptorsDavid J Lloyd, David J St Jean, Robert J M Kurzeja, et al.ACS Medicinal Chemistry Letters|June 6, 2014
A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-SecretaseMatthew R Kaller, Scott S Harried, Brian Albrecht, et al.Journal of Medicinal Chemistry|December 4, 2014
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune diseaseTimothy D Cushing, Xiaolin Hao, Youngsook Shin, et al.Journal of Medicinal Chemistry|April 4, 2012
Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloidMatthew M Weiss, Toni Williamson, Safura Babu-Khan, et al.Journal of Medicinal Chemistry|April 4, 2012
Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitorsThomas A Dineen, Matthew M Weiss, Toni Williamson, et al.Pageof 26