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Nature Communications|January 18, 2025
Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamicsThomas Vaissiere, Sheldon D Michaelson, Thomas Creson, et al.
Journal of Alzheimer'S Disease : JAD|July 18, 2020
Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 MiceKristen R Hollinger, Xiaolei Zhu, Elizabeth S Khoury, et al.
Bioorganic & Medicinal Chemistry|October 17, 2020
Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linkerBridget Duvall, Sarah C Zimmermann, Run-Duo Gao, et al.
JCI Insight|August 19, 2016
FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalitiesRana Rais, Weiwei Jiang, Huihong Zhai, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 28, 2012
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout miceRana Rais, Ajit G Thomas, Krystyna Wozniak, et al.
Anesthesia and Analgesia|July 18, 2008
Palonosetron exhibits unique molecular interactions with the 5-HT3 receptorCamilo Rojas, Marigo Stathis, Ajit G Thomas, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society|April 13, 2023
Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsyFan Zhang, Zhi Zhang, Jesse Alt, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 24, 2003
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis modelsGhanashyam D Ghadge, Barbara S Slusher, Amos Bodner, et al.
Journal of Medicinal Chemistry|November 16, 2012
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitorsKrupa Shukla, Dana V Ferraris, Ajit G Thomas, et al.
Neuron|June 20, 2014
Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neuronsEmin D Ozkan, Thomas K Creson, Enikö A Kramár, et al.
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