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ACS Medicinal Chemistry Letters|November 19, 2025
Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2 (ALK2) for the Treatment of Fibrodysplasia Ossificans ProgressivaThomas Ullrich, Sabine Guth, Luca Arista, et al.The EMBO Journal|May 31, 2008
The interaction network of the chaperonin CCTCarien Dekker, Peter C Stirling, Elizabeth A McCormack, et al.Journal of Molecular Biology|October 23, 2021
Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome InhibitionCarien Dekker, Henri Mattes, Michael Wright, et al.Journal of Medicinal Chemistry|January 4, 2024
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 InhibitorsJuraj Velcicky, Philipp Janser, Nina Gommermann, et al.Journal of Medicinal Chemistry|November 22, 2024
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 InflammasomeAngela Mackay, Juraj Velcicky, Nina Gommermann, et al.Journal of Medicinal Chemistry|March 4, 2025
Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome InhibitorDong-Ming Shen, Kate F Byth, Damien Bertheloot, et al.Pageof 2