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Biomedicines|December 30, 2025
Dual Modulation of Cardiac Ion Pumps: A Small-Molecule SERCA2a SUMOylation Enhancer Also Inhibits the Na<sup>+</sup>/K<sup>+</sup>-ATPaseCarlos Cruz-Cortés, Jaroslava Šeflová, L Michel Espinoza-Fonseca
The Journal of Membrane Biology|May 20, 2026
Fluorescence Lifetime Spectroscopy Reveals Distinct Allosteric Mechanisms of SERCA InhibitorsJaroslava Šeflová, Carlos Cruz-Cortés, Seth L Robia, et al.
Chemmedchem|November 30, 2025
Small-Molecule Sarco/Endoplasmic Reticulum Ca<sup>2+</sup>-ATPase Activators Reverse Methylglyoxal-Induced Inhibition through Nonantioxidant MechanismsCarlos Cruz-Cortés, Silvia Micháliková, Petronela Rezbáriková, et al.
Redox Biology|February 3, 2019
Regulation of stress signaling pathways by protein lipoxidationTommi Patinen, Simone Adinolfi, Carlos Cruz Cortés, et al.
PNAS Nexus|January 15, 2024
Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imagingJaroslava Šeflová, Carlos Cruz-Cortés, Guadalupe Guerrero-Serna, et al.
Biorxiv : the Preprint Server for Biology|February 12, 2026
Supercharging the calcium pump: Identification of an activation hotspot on SERCA by cryo-EMVinh H Nguyen, Carlos Cruz-Cortés, Joseph O Primeau, et al.
Journal of Medicinal Chemistry|July 24, 2025
SAR-Guided Development of Small-Molecule SERCA2a Activators: Discovery of Potent Indoline, Benzofuran, and Benzodioxole Analogs for Cardiovascular ApplicationsAdam Ard, Carlos Cruz-Cortés, Xinmin Gan, et al.
The Journal of Biological Chemistry|April 8, 2023
A novel machine learning-based screening identifies statins as inhibitors of the calcium pump SERCACarlos Cruz-Cortés, M Andrés Velasco-Saavedra, Eli Fernández-de Gortari, et al.
Chemmedchem|January 24, 2025
Machine Learning-Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2aCarlos Cruz-Cortés, Eli Fernández-de Gortari, Rodrigo Aguayo-Ortiz, et al.
International Journal of Molecular Sciences|June 26, 2025
Paradoxical SERCA2a Dysregulation Contributes to Atrial Fibrillation in a Model of Diet-Induced ObesityDaniela Ponce-Balbuena, Daniel J Tyrrell, Carlos Cruz-Cortés, et al.
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