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Journal of Medicinal Chemistry|April 18, 2003
Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPTDan Niculescu-Duvaz, Ion Niculescu-Duvaz, Frank Friedlos, et al.
Cancer Research|April 3, 2004
V599EB-RAF is an oncogene in melanocytesClaudia Wellbrock, Lesley Ogilvie, Douglas Hedley, et al.
Journal of Medicinal Chemistry|August 5, 2005
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapyLawrence C Davies, Frank Friedlos, Douglas Hedley, et al.
Cancer Research|May 19, 2007
Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2Silke Schepelmann, Lesley M Ogilvie, Douglas Hedley, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 3, 2008
Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapyFrank Friedlos, Panos Lehouritis, Lesley Ogilvie, et al.
NMR in Biomedicine|March 5, 2009
A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using 19F magnetic resonance spectroscopyLaura Mancini, Lawrence Davies, Frank Friedlos, et al.
Magnetic Resonance in Medicine|September 26, 2009
Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activityYann Jamin, Cristina Gabellieri, Lynette Smyth, et al.
NMR in Biomedicine|October 5, 2010
Noninvasive detection of carboxypeptidase G2 activity in vivoYann Jamin, Lynette Smyth, Simon P Robinson, et al.
Cancer Research|June 17, 2005
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2Silke Schepelmann, Paul Hallenbeck, Lesley M Ogilvie, et al.
Cancer Research|March 26, 2002
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft modelsFrank Friedlos, Lawrence Davies, Ian Scanlon, et al.
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