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Biopharmaceutics & Drug Disposition|March 24, 2021
When special populations intersect with drug-drug interactions: Application of physiologically-based pharmacokinetic modeling in pregnant populationsCaroline Sychterz, Aleksandra Galetin, Kunal S Taskar
International Journal of Molecular Sciences|November 25, 2023
The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution-A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic ModelingLu Gaohua, Mian Zhang, Caroline Sychterz, et al.
Journal of Clinical Pharmacology|December 18, 2024
Drug-Drug Interaction Potential of Mavacamten with Midazolam: Combined Results from Clinical and Model-Based StudiesSamira Merali, Caroline Sychterz, Vidya Perera, et al.
CPT: Pharmacometrics & Systems Pharmacology|October 1, 2022
A perspective on the current use of the phase distribution model for predicting milk-to-plasma drug concentration ratioMian Zhang, Caroline Sychterz, Ming Chang, et al.
Pharmacology Research & Perspectives|October 31, 2015
Interrogating the relationship between rat in vivo tissue distribution and drug property data for >200 structurally unrelated moleculesAndrew W Harrell, Caroline Sychterz, May Y Ho, et al.
Clinical Pharmacology and Therapeutics|July 19, 2023
Physiologically Based Pharmacokinetic Modeling and Simulation of Mavacamten Exposure with Drug-Drug Interactions from CYP Inducers and Inhibitors by CYP2C19 PhenotypeManting Chiang, Caroline Sychterz, Vidya Perera, et al.
Journal of Clinical Pharmacology|June 28, 2023
Drug-Drug Interaction Potential of Mavacamten with Oral Contraceptives: Results from a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic ModelManting Chiang, Caroline Sychterz, Lu Gaohua, et al.
The AAPS Journal|April 29, 2025
Model-informed Drug Development (MIDD) Approach to Support Biopharmaceutical Development of IberdomideCaroline Sychterz, Ping Chen, Ajay Saxena, et al.
Journal of Clinical Pharmacology|August 12, 2025
Exposure-Response Modeling and Simulation to Identify Optimal Mavacamten Posology When Coadministered with CYP3A4 and CYP2C19 Inhibitors in Patients with Obstructive HCMSamira Merali, Haden Bunn, Caroline Sychterz, et al.
CPT: Pharmacometrics & Systems Pharmacology|September 18, 2024
A close examination of BCRP's role in lactation and methods for predicting drug distribution into milkCaroline Sychterz, Hong Shen, Yueping Zhang, et al.
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