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Bioorganic & Medicinal Chemistry Letters|June 27, 2008
Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluationChristopher M Tegley, Vellarkad N Viswanadhan, Kaustav Biswas, et al.Cancer Cell|April 26, 2024
Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancersSarah T Diepstraten, Yin Yuan, John E La Marca, et al.Cell Death and Differentiation|February 4, 2023
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cellsZilu Wang, Huimin Hu, Luuk Heitink, et al.Cell Death and Differentiation|December 14, 2023
Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responsesJohn E La Marca, Brandon J Aubrey, Bruce Yang, et al.Hepatology (Baltimore, Md.)|May 1, 2026
BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of diseaseBritta Handyside, Heather Wenzel, Donald Mackenzie, et al.Cell Death and Differentiation|October 25, 2019
EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteinsLeah Fitzsimmons, Rachel Cartlidge, Catherine Chang, et al.Haematologica|June 6, 2024
Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphomaNicholas Davies, Tegan Francis, Ceri Oldreive, et al.Cancer Discovery|October 25, 2023
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer CellsZilu Wang, Matteo Burigotto, Sabrina Ghetti, et al.Nature Communications|October 22, 2024
In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditionsGeorgia K Atkin-Smith, Jascinta P Santavanond, Amanda Light, et al.Nature Communications|November 28, 2018
VDAC2 enables BAX to mediate apoptosis and limit tumor developmentHui San Chin, Mark X Li, Iris K L Tan, et al.Pageof 6