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Journal of Medicinal Chemistry|August 12, 2025
Discovery and In-Vivo Characterization of Kv7 Channel Openers through a Phenotypic ApproachRomain Siegrist, Olivier Bezençon, Caroline Deymier, et al.Journal of Medicinal Chemistry|May 5, 2025
Discovery of a New Class of Orexin 2 Receptor Agonists as a Potential Treatment for NarcolepsyDavide Pozzi, Romain Siegrist, Jens-Uwe Peters, et al.Inorganic Chemistry|May 10, 2019
Fluorescent Zr(IV) Metal-Organic Frameworks Based on an Excited-State Intramolecular Proton Transfer-Type LigandVirgile Trannoy, Nathalie Guillou, Carine Livage, et al.Bioorganic & Medicinal Chemistry Letters|October 26, 2017
Discovery and evaluation of Cav3.1-selective T-type calcium channel blockersOlivier Bezençon, Luboš Remeň, Sylvia Richard, et al.Chemical Communications (Cambridge, England)|January 17, 2015
Immobilization of polyoxometalates in the Zr-based metal organic framework UiO-67William Salomon, Catherine Roch-Marchal, Pierre Mialane, et al.Bioorganic & Medicinal Chemistry Letters|October 28, 2017
Discovery and evaluation of Cav3.2-selective T-type calcium channel blockersOlivier Bezençon, Luboš Remeň, Sylvia Richard, et al.Chemmedchem|September 16, 2020
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia DisordersChristoph Boss, John Gatfield, Christine Brotschi, et al.Chemmedchem|May 9, 2019
Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in RatsChristine Brotschi, Catherine Roch, John Gatfield, et al.Chemmedchem|January 17, 2020
From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in DogsChristine Brotschi, Martin H Bolli, John Gatfield, et al.The Journal of Pharmacology and Experimental Therapeutics|July 1, 2017
The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468Alexander Treiber, Ruben de Kanter, Catherine Roch, et al.Pageof 6