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Journal of Medicinal Chemistry|November 23, 2013
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's diseaseRoland W Bürli, Christopher A Luckhurst, Omar Aziz, et al.Journal of Medicinal Chemistry|March 7, 2019
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease ModelsLeticia Toledo-Sherman, Perla Breccia, Roger Cachope, et al.Journal of Medicinal Chemistry|January 10, 2012
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's diseaseMichael E Prime, Ole A Andersen, John J Barker, et al.Journal of Medicinal Chemistry|January 16, 2015
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's diseaseLeticia M Toledo-Sherman, Michael E Prime, Ladislav Mrzljak, et al.Journal of Medicinal Chemistry|March 12, 2015
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitorsJohn Wityak, Kevin F McGee, Michael P Conlon, et al.Journal of Medicinal Chemistry|August 5, 2021
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological ProteinsLongbin Liu, Peter D Johnson, Michael E Prime, et al.Journal of Medicinal Chemistry|December 22, 2022
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin AggregatesLongbin Liu, Peter D Johnson, Michael E Prime, et al.Journal of Medicinal Chemistry|July 7, 2025
Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin AggregatesLongbin Liu, Peter D Johnson, Matthew R Mills, et al.Journal of Medicinal Chemistry|July 15, 2020
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET LigandLongbin Liu, Michael E Prime, Matt R Lee, et al.Journal of Medicinal Chemistry|September 15, 2023
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's DiseaseLongbin Liu, Karine Malagu, Alan F Haughan, et al.Pageof 9